{"id":6097,"date":"2022-06-09T17:05:40","date_gmt":"2022-06-09T15:05:40","guid":{"rendered":"https:\/\/www.defe.fr\/main-research-areas\/axis-no-2-gamete-competence-embryo-and-implantation\/"},"modified":"2026-03-06T11:56:01","modified_gmt":"2026-03-06T10:56:01","slug":"axis-no-2-gamete-competence-embryo-and-implantation","status":"publish","type":"page","link":"https:\/\/www.defe.fr\/en\/main-research-areas\/axis-no-2-gamete-competence-embryo-and-implantation\/","title":{"rendered":"AXIS No. 2: Gamete Competence (Embryo and Implantation)"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; gradient_type=&#8221;default&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][tabbed_section style=&#8221;vertical_scrolling&#8221; tab_color=&#8221;Accent-Color&#8221; vs_navigation_func=&#8221;default&#8221; vs_navigation_width=&#8221;regular&#8221; vs_navigation_spacing=&#8221;15px&#8221; vs_navigation_mobile_display=&#8221;visible&#8221; vs_tab_spacing=&#8221;5%&#8221; vs_tab_tag=&#8221;p&#8221; vs_cta_style=&#8221;see-through&#8221; vs_cta_bg_color=&#8221;default&#8221; vs_cta_heading_tag=&#8221;h6&#8243; vs_sticky_aspect=&#8221;default&#8221;][tab icon_family=&#8221;none&#8221; title=&#8221;1 &#8211; Human Fallopian Tube Organoids&#8221; id=&#8221;1695123644239-9&#8243; tab_id=&#8221;1695123644240-7&#8243;][vc_column_text]\n<h2>1 &#8211; Human Fallopian Tube Organoids<\/h2>\n<p>Researchers who have worked on this axis:<\/p>\n<ul>\n<li>Prof. E. Huyghe<\/li>\n<li>Dr. N. Gatimel<\/li>\n<li>Dr. G. Perez<\/li>\n<\/ul>\n<p>To contact a reference person on this research axis, please call Fran\u00e7oise Paris at <a href=\"tel:+33615106371\"><strong>06 15 10 63 71<\/strong><\/a>.[\/vc_column_text][vc_column_text el_class=&#8221;amd-justify-text&#8221;]\n<h3>a) Issue<\/h3>\n<p>Despite advances in ART, live birth rates per IVF attempt remain relatively low. These results are largely determined by the competence of the embryos obtained during IVF. The <strong>competence<\/strong> of the embryos obtained is determined by that <strong>of the gametes<\/strong> from which they originate, as well as by the technical conditions implemented for the stages of fertilization, embryonic development, or cryopreservation. <strong>The competence of spermatozoa is among other things highly dependent on their tubal journey<\/strong>, although the mechanisms remain poorly understood.[\/vc_column_text][image_with_animation image_url=&#8221;6043&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][vc_column_text]\n<h3>b) Human Fallopian Tube Organoids Project<\/h3>\n[\/vc_column_text][image_with_animation image_url=&#8221;6042&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][image_with_animation image_url=&#8221;6041&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][vc_column_text]These tubal organoids should improve understanding of tubal physiology as well as the environment favorable to gamete survival and preimplantation embryo development. This knowledge may also contribute to improving Assisted Reproductive Technology techniques.[\/vc_column_text][\/tab][\/tabbed_section][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; gradient_type=&#8221;default&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":6089,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6097","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/pages\/6097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/comments?post=6097"}],"version-history":[{"count":1,"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/pages\/6097\/revisions"}],"predecessor-version":[{"id":6103,"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/pages\/6097\/revisions\/6103"}],"up":[{"embeddable":true,"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/pages\/6089"}],"wp:attachment":[{"href":"https:\/\/www.defe.fr\/en\/wp-json\/wp\/v2\/media?parent=6097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}